2023
Zhang L, Lee M, Maslov AY, Montagna C, Vijg J, Dong X. Analyzing somatic mutations by single-cell whole-genome sequencing. Nature Protocols. 2023 Nov 23. doi: 10.1038/s41596-023-00914-8. PMID: 37996541.
Zhang L, Cecco MD, Lee M, Hao X, Maslov AY, Dong X#, Sedivy JM#, Vijg J#. Single-cell whole-genome sequencing discovers accumulation of somatic mutations during cellular senescence. Under revision. (Co-corresponding author)
Zhang L#, Lee M, Maslov AY, Vijg J, Dong X#. Single-cell whole-genome sequencing for discovering somatic mutations. Under revision. (#Co-corresponding author)
Shea A, Bartz J, Zhang L, Dong X. Predicting mutational function using machine learning. Under revision.
Bartz J, Jung H, Wasiluk K, Zhang L, Dong X#. Progress in Discovering Transcriptional Noise in Aging. Int. J. Mol. Sci. 2023, 23.
View all PubMed Publications
2021
Zhang L#, Dong X, Tian X, Lee M, Ablaeva J, Firsanov D, Lee SG, Maslov AY, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J. Maintenance of genome sequence integrity in long-and short-lived rodent species. Sci. Adv. 2021 Oct 29;7(44): eabj3284. doi: 10.1126/sciadv.abj3284. PubMed PMID: 34705500. (#Co-corresponding author)
Zhang Q, Tombline G, Ablaeva J, Zhang L, Zhou X, Smith Z, Zhao Y, Xiaoli AM, Wang Z, Lin JR, Jabalameli MR, Mitra J, Nguyen N, Vijg J, Seluanov A, Gladyshev VN, Gorbunova V, Zhang ZD. Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation. Cell Rep. 2021 Nov 9;37(6):109965.
Dong X, Sun S, Zhang L*, Kim S, Tu Z, Montagna C, Maslov AY., Suh Y, Wang T, Campisi J, Vijg J. Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions. Aging Cell. 2021 Jun;20(6):e13357. (*Co-first author)
2020
Dong X, Zhang L, Hao X, Wang T, Vijg J. SCCNV: A software tool for identifying copy number variation from single-cell whole-genome sequencing. Front Genet. 2020 Nov 16. 11:505441. doi: 10.3389/fgene.2020.505441. PubMed PMID: 33304377.
2019
Zhang L, Dong X, Lee M, Maslov AY, Wang T, Vijg J. Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. Proc Natl Acad Sci U S A. 2019 Apr 16. pii: 201902510. doi: 10.1073/pnas. PubMed PMID: 30992375.
2018
Zhang L, Vijg J. Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging. Annual Review of Genetics. 2018;52:397-419. Epub 2018/09/14. doi: 10.1146/annurev-genet-120417-031501. PubMed PMID: 30212236; PMCID: PMC6414224.
2017
Vijg J, Dong X, Zhang L. A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden. Experimental Biology and Medicine. 2017;242(13):1318-24. Epub 2017/07/25. doi: 10.1177/1535370217717696. PubMed PMID: 28737476; PMCID: PMC5529006.
Vijg J, Dong X, Milholland B, Zhang L. Genome instability: a conserved mechanism of ageing? Essays in Biochemistry. 2017;61(3):305-15. Epub 2017/05/28. doi: 10.1042/EBC20160082. PubMed PMID: 28550046; PMCID: PMC5988260.
Milholland B, Dong X, Zhang L*, Hao X, Suh Y, Vijg J. Differences between germline and somatic mutation rates in humans and mice. Nature Communications. 2017;8:15183. Epub 2017/05/10. doi: 10.1038/ncomms15183. PubMed PMID: 28485371; PMCID: PMC5436103. (*Co-first author)
Dong X, Zhang L, Milholland B, Lee M, Maslov A, Wang T, Vijg J. Single-Cell Multiple Displacement Amplification (SCMDA). Protocol Exchange. 2017. doi: 10.1038/protex.2017.061
Dong X, Zhang L*, Milholland B, Lee M, Maslov AY, Wang T, Vijg J. Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nature Methods. 2017;14(5):491-3. Epub 2017/03/21. doi: 10.1038/nmeth.4227. PubMed PMID: 28319112; PMCID: PMC5408311. (*Co-first author)
Before 2017
Nie X, Yang B, Zhang L, Gu Y, Yang S, Jiang W, Yang C. PTS regulation domain-containing transcriptional activator CelR and sigma factor sigma(54) control cellobiose utilization in Clostridium acetobutylicum. Molecular Microbiology. 2016;100(2):289-302. Epub 2015/12/23. doi: 10.1111/mmi.13316. PubMed PMID: 26691835.
Zhang L, Nie X, Ravcheev DA, Rodionov DA, Sheng J, Gu Y, Yang S, Jiang W, Yang C. Redox-responsive repressor Rex modulates alcohol production and oxidative stress tolerance in Clostridium acetobutylicum. Journal of Bacteriology. 2014;196(22):3949-63. Epub 2014/09/04. doi: 10.1128/jb.02037-14. PubMed PMID: 25182496; PMCID: PMC4248821.
Liu L, Zhang L*, Tang W, Gu Y, Hua Q, Yang S, Jiang W, Yang C. Phosphoketolase pathway for xylose catabolism in Clostridium acetobutylicum revealed by 13C metabolic flux analysis. Journal of Bacteriology. 2012;194(19):5413-22. Epub 2012/08/07. doi: 10.1128/jb.00713-12. PubMed PMID: 22865845; PMCID: PMC3457242. (*Co-first author)
Zhang L, Leyn SA, Gu Y, Jiang W, Rodionov DA, Yang C. Ribulokinase and transcriptional regulation of arabinose metabolism in Clostridium acetobutylicum. Journal of Bacteriology. 2012;194(5):1055-64. Epub 2011/12/24. doi: 10.1128/jb.06241-11. PubMed PMID: 22194461; PMCID: PMC3294803.
Gu Y, Li J, Zhang L, Chen J, Niu L, Yang Y, Yang S, Jiang W. Improvement of xylose utilization in Clostridium acetobutylicum via expression of the talA gene encoding transaldolase from Escherichia coli. Journal of Biotechnology. 2009;143(4):284-7. Epub 2009/08/22. doi: 10.1016/j.jbiotec.2009.08.009. PubMed PMID: 19695296.