The Zhang Lab

The Zhang Lab is part of the Institute on the Biology of Aging and Metabolism and Medical Discovery Team on Aging at the University of Minnesota.

The general interest of the Zhang Laboratory focuses on genome and epigenome instability in aging and longevity. More specifically we study somatic DNA mutations and epi-mutations and their effects on cellular functional decline in normal aging process or age-related diseases. We have been developing experimental approaches of single-cell multi-omics and applying them to discover interactions of genome, transcriptome and epigenome in individual cells from different tissues of humans during aging or species with different maximum life spans.